Optic flow refers to the visual motion pattern that occurs due to relative motion between an observer and their surrounding environment. This flow pattern contains information about the observer’s direction and speed of self-motion, as well as the three-dimensional structure of the environment. The processing of optic flow begins in the primary visual cortex (V1), where neurons sensitive to motion direction and speed extract local motion signals from the flow pattern. These signals are then integrated in higher cortical areas to determine heading direction and speed. Key areas involved are V5/MT, MST, VIP, and CSv. Neurons in V5/MT integrate local motion signals into component patterns of radial, rotational, and translational flow. MST receives input from MT and contains neurons selective for expansion/contraction flow, spiral motion, and translational flow patterns. Combinations of these patterns allow MST neurons to signal heading direction. The ventral intraparietal area (VIP) also receives input from MT and contains neurons tuned to optic flow components and heading direction. VIP plays a key role in using optic flow for navigation and steering control. The cingulate sulcus visual area (CSv) further integrates optic flow signals to extract egomotion information. CSv connects to areas involved in motor control and navigation.