The somatotropic axis regulates growth hormone (GH) secretion from the anterior pituitary. This process is controlled by two hypothalamic hormones – growth hormone releasing hormone (GHRH) and somatostatin [1][2]. GHRH is secreted from the arcuate nucleus and stimulates GH release. Somatostatin is secreted from the periventricular nucleus and inhibits GH release [1][3]. Dopamine acts both directly on somatotrophs and indirectly by modulating GHRH and somatostatin release [4][5]. Dopamine inhibits GH, likely by stimulating somatostatin secretion [3][6]. Ghrelin and neuropeptide Y stimulate GH, potentially by inhibiting somatostatin [1][5]. Negative feedback by IGF-1 suppresses GHRH release [4][6]. Together, these neural signals regulate pulsatile GH secretion to support growth and metabolism.